Prion protein and aging
نویسندگان
چکیده
منابع مشابه
Prion protein and aging
The cellular prion protein (PrP(C)) has been widely investigated ever since its conformational isoform, the prion (or PrP(Sc)), was identified as the etiological agent of prion disorders. The high homology shared by the PrP(C)-encoding gene among mammals, its high turnover rate and expression in every tissue strongly suggest that PrP(C) may possess key physiological functions. Therefore, defini...
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The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we r...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2014
ISSN: 2296-634X
DOI: 10.3389/fcell.2014.00044